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Inhibitory Effects of Three Philippine Medicinal Plants on Somatic and Germ Cell Genotoxicity

The Bulletin of Philippine Biochemical Society
​Volume 9, Issue 1, 1990, Pages 5-9​
                                                
Authors
Gemma P. Geslani**, Clara Y. Lim-Sylianco*** and Angelita G. Reyes**

*Portion of the MS thesis of the Senior Author
**Dept. of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines - Manila
***Institute of Chemistry, University of the Philippines - Diliman, Quezon City

Abstract
     Three medicinal plants, ampalaya, kamias and makabuhay possessing fertility regulating properties were screened for mutagenic and antimutagenic activity.
          The micronucleus test showed that the plants did not have chromosome breaking effects on mammalian somatic cells. Rather, they were anticlastogenic against dimethylnitrosamine (DMN) and tetracycline HCl. The dominant lethal assay proved that the samples were non-mutagenic to germ cells. The test plants also exhibited antigenotoxicity against tetracycline HCl.

Keywords: medicinal plants, somatic/germ cell genotoxicity, amapalaya, kamias, makabuhay.

To cite this article
G.P. Geslani, C.Y. Lim-Sylianco and A.G. Reyes​, Inhibitory Effects of Three Philippine Medicinal Plants on Somatic and Germ Cell Genotoxicity, The Bulletin of Philippine Biochemical Society, Vol. 9, No. 1, 1990, pp.  5-10​. 
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