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Mutagenicity and Clastogenicity Potential of Decoctions and Infusions from Philippine Medicinal Plants

The Bulletin of Philippine Biochemical Society
​Volume 3, Issue 1 & 2, 1980, Pages 54-65
                                      
Authors
C.Y. Lim-Sylianco*, J.A. Concha**, J. San Agustin, I. Panizares and C. Pablo 

*Dept. of Chemistry, College of Arts & Sciences, and
​**College of Pharmacy, University of the Philippines - Diliman 

Abstract
            The Philippine National Formulary lists Philippine plants whose decoctions and infusions are used for medicinal purposes. Mutagenicity potential of these decoctions and infusions were studied without metabolic activation and after metabolic activation. Without metabolic activation, decoction from leaves of Plantage major L. and decoctions from leaves and bark of Pittosporum pentandrum (Blanco) Merr. induced frameshift mutagenesis in Salmonella typhimurium. After metabolism in the experimental mice, these induced both base-pair and frameshift mutagenesis. Decoctions from bark of Pitchecolobium dulce (Roxb.) Benth. induced base-pair mutagenesis without metabolic activation. Upon metabolic activation in the mice, this tendency was lost. Instead it induced frameshift mutations. Decoctions from stems of Arcangelisia fava (L.) Merr. induced both base-pair and frameshift mutations without metabolic activation. Hoewever, this mutagenic property was lost upon metabolism in the experimental mice.
             The following are non-mutagenic before and after metabolism:
  1. Decoctions from leaves of Citrus documana L., Eucalyptus deglupta Blume, Moringa oleifera Lam., Pandanus odoratissimus L. Persea American Mill., Psidium guajava L., Sterculea feotida L. and Tamarindus indica L.
  2. Decoctions from plants of Apium graveolens L., Mimosa pudica Linn., Rosmarinus officinalis L. and Solanum nigrum L.
  3. Decoctions from bark of Mangifera indica L., and Michelina champaca L.
  4. Decoctions from kernel of Arecha catechu L., from bran of Oryza sativa L. and from hair and cob of Zea mays L.
  5. Infusions from leaves of Momordica balsamina Blanco, from bark and leaves of Anacardium occidentale L., from fruit of Foeniculum vulgare L., and from leaves of Mangifera indica L.
        Clastogenicity or chromosome breaking potential was exhibited by decoctions from leaves and bark of Pittosporum pantandrum (Blanco) Merr., decoctions from leaves of Plantago major L., decoctions from leaves of Eucalyptus deglupta Blume and decoctions from cobs of Zea mays L. Infusions from leaves of Anacardium occidentale L. also showed chromosome breaking effects.

To cite this article
C.Y. Lim-Sylianco, J.A. Concha, J. San Agustin, I. Panizares and C. Pablo, Mutagenicity and Clastogenicity Potential of Decoctions and Infusions from Philippine Medicinal Plants, The Bulletin of Philippine Biochemical Society, Vol. 3, No. 1 & 2, 1980, pp. 54-65.     
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