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Cancer Promoters and Germ Cell Toxicity of Dimethylnitrosamine. Effects of phenobarbital and saccharin

The Bulletin of Philippine Biochemical Society
​Volume 11 & 12, Issue 1, 1992-1993, Pages 16-18
                                                
Authors
Dalisay Chionglo Sy and Lumina Eugenio

Dept. of Biochemistry, Faculty of Medicine and Surgery, University of Santo Tomas, Manila
​
Abstract                                                                                       
          Studies in the past have shown the enhancing actions of phenobarbital and saccharin on somatic cell toxicity of dimethylnitrosamine. This paper deals with the effects of the two substances on the genotoxicity of DMN. Nine to 10 weeks old Strong A male mice were treated with DMN at zero time, followed by phenobarbital and saccharin after one hour. One week after treatment, animals were mated with virgin females and subsequently impregnated mice were observed for dead implants and dominant lethals. Average total live embryo for animals treated with DMN and phenobarbital or saccharin did not show significant difference from controls. However animals that received DMN and saccharin exhibited marked increase in percent dead implants compared to controls. Those that received DMN and phenobarbital showed appreciable increase in the percent dead implants only at the phenobarbital dose of 120 mg per kg Body Weight.

Keywords: promotion, germ cell toxicity, phenobarbital, saccharin.
            
To cite this article
D.C. Sy and L. Eugenio​, Isolation, Cancer Promoters and Germ Cell Toxicity of Dimethylnitrosamine. Effects of phenobarbital and saccharin, The Bulletin of Philippine Biochemical Society, Vol. 11 & 12, No. 1, 1992-1993, pp.  16-18. 
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