Philippine Society of Biochemistry and Molecular Biology
  • Home
  • About
    • Constitution and By Laws
    • Board of Directors
    • Membership
    • Awards and Grants >
      • Awardees
      • Young Scientists' Forum
    • PSBMB Chapters >
      • North Luzon Chapter
      • Central Luzon Chapter
      • South Luzon Chapter
  • Conventions
    • 47th Annual Convention
    • 46th Annual Convention
    • 45th Annual Convention
  • RevUp and REdUp
    • 1st REdUp
    • 18th Review and Updates
  • News
  • Newsletter
  • PJBMB
HOME
PROCESSING CHARGES
ARCHIVE
INDEXING
SPECIAL ISSUES
PUBLICATION ETHICS
NEWS
COPYRIGHT
EDITORIAL TEAM
CONTACT US
SUBMISSION & GUIDELINES
FAQs

Archive

1978, volume 1
  • June 1978, Vol. 1, Issue 1
  • December 1978, Vol. 1, Issue 2​
1979, volume 2​
  • June 1979, Vol. 2, Issue 1
1980, volume 3
  • December 1980, Vol. 3, Issue 1 & 2
1981, volume 4
  • December 1981, Vol. 4, Issue 1 & 2
1982-1983, volume 5 & 6
  • 1982-1983, Vol. 5 & 6, Issue 1
1987, volume 7
  • June 1987, Vol. 7, Issue 1
  • December 1987, Vol. 7, Issue 2​
1988-1989, volume 8
  • Vol. 8, Issue 1
1990, volume 9
  • Vol. 9, Issue 1
1992-1993, VOLUME 11 & 12
  • Vol. 11 & 12, Issue 1​

Cancer Promoters and Germ Cell Toxicity of Dimethylnitrosamine. Effects of phenobarbital and saccharin


The Bulletin of Philippine Biochemical Society
​Volume 11 & 12, Issue 1, 1992-1993, Pages 16-18
                                                
Authors
Dalisay Chionglo Sy and Lumina Eugenio

Dept. of Biochemistry, Faculty of Medicine and Surgery, University of Santo Tomas, Manila
​
Abstract                                                                                       
          Studies in the past have shown the enhancing actions of phenobarbital and saccharin on somatic cell toxicity of dimethylnitrosamine. This paper deals with the effects of the two substances on the genotoxicity of DMN. Nine to 10 weeks old Strong A male mice were treated with DMN at zero time, followed by phenobarbital and saccharin after one hour. One week after treatment, animals were mated with virgin females and subsequently impregnated mice were observed for dead implants and dominant lethals. Average total live embryo for animals treated with DMN and phenobarbital or saccharin did not show significant difference from controls. However animals that received DMN and saccharin exhibited marked increase in percent dead implants compared to controls. Those that received DMN and phenobarbital showed appreciable increase in the percent dead implants only at the phenobarbital dose of 120 mg per kg Body Weight.

Keywords: promotion, germ cell toxicity, phenobarbital, saccharin.
            
To cite this article
D.C. Sy and L. Eugenio​, Isolation, Cancer Promoters and Germ Cell Toxicity of Dimethylnitrosamine. Effects of phenobarbital and saccharin, The Bulletin of Philippine Biochemical Society, Vol. 11 & 12, No. 1, 1992-1993, pp.  16-18. 
Picture
Abstract

Picture
 ​ ​PDF


​SOCIETY PROJECTS
Journals
News
Conventions
RevUp
JOIN US
Apply as an Editor
Apply as an Editorial Board Member/Reviewer
Qualifications & Requirements
RESOURCES
Open access
For Authors
For Librarians
For Booksellers
Processing Charges
SPECIAL SERVICES
Download Certificates
Recommend to Library
Ordering from PJBMB
Subscribe
Unsubscribe
ADDRESS
Philippine Journal of Biochemistry and Molecular Biology
College of Medicine,
University of the Philippines
547 Pedro Gil St., Ermita
Metro Manila 1000
Tel: (02) 526 4197
Powered by Create your own unique website with customizable templates.
  • Home
  • About
    • Constitution and By Laws
    • Board of Directors
    • Membership
    • Awards and Grants >
      • Awardees
      • Young Scientists' Forum
    • PSBMB Chapters >
      • North Luzon Chapter
      • Central Luzon Chapter
      • South Luzon Chapter
  • Conventions
    • 47th Annual Convention
    • 46th Annual Convention
    • 45th Annual Convention
  • RevUp and REdUp
    • 1st REdUp
    • 18th Review and Updates
  • News
  • Newsletter
  • PJBMB