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Inhibitory Effects of Butylated Hydroxyanisole and Butylated Hydroxytoluene on the Genotoxicity of Some Anticancer Drugs​

The Bulletin of Philippine Biochemical Society
​Volume 9, Issue 1, 1990, Pages 1-4
                                                
Authors
C.Y. Lim-Sylianco, E. Evallo, B.C.T. Bascug and C.H. Purugganan

*Dept. of Chemistry, College of Science, University of the Philippines - Diliman, Quezon City

Abstract                                                                             
     Busulfan, chlorambucil and cyclophosphamide, the three anticancer agents, did not exhibit direct DNA damaging capacity in in vitro test using Rec assay. However, in vivo studies using the micronucleus test, showed that these drugs are mutagenic and clastogenic.
   Two antioxidants, butylated hydroxyanisole and butalated hydrozytoluene reduced the genotoxic effects of the three anticancer agents as shown by the significant reduction of micronucleated polychromatic erythrocytes in bone marrow cells of mice.

​Keywords: butylated hydroxyanisole, butylated hydrozytoluene, genotoxicity antioxidants.


To cite this article
C.Y. Lim-Sylianco, E. Evallo, B.C.T. Bascug and C.H. Purugganan​, Inhibitory Effects of Butylated Hydroxyanisole and Butylated Hydroxytoluene on the Genotoxicity of Some Anticancer Drugs, The Bulletin of Philippine Biochemical Society, Vol. 9, No. 1, 1990, pp.  1-4. 
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