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Mutagenic and Clastogenic Potential of Some Anti-Hypertensive Drugs

The Bulletin of Philippine Biochemical Society
​Volume 2, Issue 1, 1979, Pages 52-59
​
Authors
Clara Y. Lim-Sylianco, Cynthia B. Pablo and Imelda Panizares *

*Dept. of Chemistry, University of the Philippines - Diliman

Abstract
        Some antihypertensive drugs containing reserpine, hydrochlorthiazide, bendroflumenthiazide, mefrusside and inositol isonicotinate were studied to determine their tendency to affect the structure of DNA.
       The DNA damaging interactions of reserpine was suggested by its inhibitory effect on the growth of recombination repair deficient strain of Bacillus subtilis. Without metabolic activation, reserpine induced frameshift mutations in Salmonella typhimurium mutants. In the experimental mouse, reserpine was metabolized to a base-pair mutagen. Its tendency to induce frameshift mutations was still observed even after metabolism in the mammalian system. In addition, reserpine exhibited clastogenic or chromosome breaking effects.
  All these properties were no observed when reserpine was in combination withbendroflumethiazide, mefrusside and inositol isonicotinate. On the other hand, its mutagenic and clastogenic effects were enhanced when it was combined with hydralazine  hydrochloride and hydrochlorthiazide.

To cite this article
C.Y. Lim-Sylianco, C.B. Pablo and I. Panizares, Mutagenic and Clastogenic Potential of Some Anti-Hypertensive Drugs, The Bulletin of Philippine Biochemical Society, Vol. 2, No. 1, 1979, pp. 52-59.     
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