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Mutangenic and Clastogenic Effects of Chloroform                                   ​

The Bulletin of Philippine Biochemical Society
​Volume 1, Issue 2, 1978, Pages 17-23

Authors
Jovenal San Agustin and Clara Y. Lim-Sylianco*
         
*University of the Philippines - Diliman, Quezon City

Abstract
            Chloroform was shown to exhibit DNA damaging capacity. However, its DNA damaging capacity is not a consequence of its direct reactivity with DNA. Directly, it did not effect base pair and frameshift mutations. But chloroform is metabolized to a frameshift mutagen in the male mouse. Thus, chloroform is a pro-mutagen, although it is not a direct mutagen. It is not only a pro-mutagen but also a clastogen (chromosome breaking). Its clastogenicity and mutagenicity, however, is reduced in the presence of vitamin E.
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To cite this article
J. San Agustin and C.Y. Lim-Sylianco​, Mutangenic and Clastogenic Effects of Chloroform, The Bulletin of Philippine Biochemical Society, Vol. 1, No. 2, 1978, pp. 17-23.      
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