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The Effects of Oral Contraceptive on Thiamine Nutriture

The Bulletin of Philippine Biochemical Society
​Volume 1, Issue 2, 1978, Pages 41-56
​
Authors
Rhodora F. Cariño-Estacio* and Manuel P. Macapinlac**
          
*College of Pharmacy, University of Santo Tomas, Manila
**Dept. of Biochemistry, University of the Philippines - Manila, College of Medicine
 
Abstract
               The effect of synthetic hormones contained in oral contraceptive agents on the erythrocyte transketolase activity (ETKA) and on thiamine metabolism was studied. An initial cross sectional study of some Filipino oral contraceptive agent users indicate that they significantly lower erythrocyte transketolase activity, but no significant TPP (Thiamine Pyrophosphate) effect when compared with a group of women of similar age and socio-economic status, some of whom were using contraceptive methods other than the “pill”.
            To determine specifically the effect of synthetic hormones on thiamine nutriture particularly when the intake of thiamine is marginal, longitudinal studies using controlled dietary intakes were done in the female albino rat. Neither the synthetic estrogen nor a combination of the synthetic estrogen and the synthetic progesterone has any effect on the ETKA and its stimulation with TPP. The excretion rate of administered 14C-thiazole labeled thiamine in the urine was also not affected by the synthetic hormones. Similarly, the synthetic hormone did not cause any significant difference in the amount of radioactivity in the liver and RBC as well as the level of free thiamine in the liver of the experimental animals.
               The result of the histological examination of the ovarian sections of rats treated with the oral contraceptive showed that the dose of the oral contraceptive used was not effective  in inhibiting ovulation, although the dosage used depressed appetite.
           Since species differences on the effects of oral contraceptive drugs on metabolism are possible, caution must be exercised in extrapolating the results and conclusion of this study to humans.

To cite this article
R.F. Cariño-Estacio and M.P Macapinlac​, The Effects of Oral Contraceptive on Thiamine Nutriture, The Bulletin of Philippine Biochemical Society, Vol. 1, No. 2, 1978, pp. 41-56.      
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